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THR-β agonist 11

CAT: 0804-HY-178015Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178015Size:1 Each
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Description
THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases[1].
CAS Number
3051970-23-8
UNSPSC
12352005
Target
Thyroid Hormone Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
CC1=CC(OC[P@]2(OCC[C@H](O2)C3=CC=CC(Cl)=C3)=O)=CC(C)=C1CC4=NNC(C(C(C)C)=C4)=O
Molecular Formula
C26H30ClN2O5P
Molecular Weight
516.95
References & Citations
[1]Lin C, et al. Design, synthesis, and biological evaluation of liver-targeting phosphoric acid thyroid hormone receptor agonists for the treatment of metabolic dysfunction-associated steatohepatitis. Bioorg Chem. 2025 Sep;164:108880.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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