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THR-β agonist 9

CAT: 0931-T210706-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210706-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2920045-74-3
Target
Acetyl-CoA Carboxylase, AMPK, Mitochondrial Metabolism, Thyroid hormone receptor (THR)
Related Pathways
Endocrinology/Hormones, PI3K/Akt/mTOR signaling, Metabolism, Chromatin/Epigenetic
Bioactivity
THR-β agonist 9 is a potent and selective THR-β activator, which shows sensitivity to His435 mutations with an EC50 of 3.2 nM. It demonstrates moderate selectivity, approximately 10-fold, and effectively activates various His435 mutants (H435A, H435Y, and H435R), with EC50 values ranging from 134.2 nM to 515.5 nM. THR-β agonist 9 presents potential for research into conditions such as dyslipidemia, metabolic syndrome-associated steatohepatitis (MASH), and resistance to thyroid hormone (RTH) .
Smiles
O=C(O)CNC(=O)C1=NC(OC)=C2C=C(OC=3C=CC=4C=CC=CC4C3)C=CC2=C1O
Molecular Formula
C23H18N2O6
Molecular Weight
418.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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