THR-β agonist 6

THR-β agonist 6

• CAS Number: 2791290-58-7
• UNSPSC Description: THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research[1].
• Target Antigen: Thyroid Hormone Receptor
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/thr-β-agonist-6.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)N1C(C=CC2=C1C=CN2C3=C(Cl)C=C(N4N=C(C#N)C(NC4=O)=O)C=C3Cl)=O
• Molecular Weight: 457.27
• References & Citations: [1]Liuyu Hu, et al. Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2023 Mar 9;66(5):3284-3300.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported