THR-β agonist 6

• UNSPSC Description:

  THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research[1].

• Target Antigen:

  Thyroid Hormone Receptor

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/thr-β-agonist-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)N1C(C=CC2=C1C=CN2C3=C(Cl)C=C(N4N=C(C#N)C(NC4=O)=O)C=C3Cl)=O

• Molecular Weight:

  457.27

• References & Citations:

  [1]Liuyu Hu, et al. Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2023 Mar 9;66(5):3284-3300.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2791290-58-7