HDAC-IN-96

• Description :

  HDAC-IN-96 (Compound 3f) is a selective HDAC1/2 inhibitor with IC50 values of 457.1 and 433.7 nM. HDAC-IN-96 has strong inhibitory activity against multiple hematological tumor cells (RS4;11, K562, RPMI-8226, U266), with IC50 values ranging from 2.11 to 5.35 μM. HDAC-IN-96 can induce cancer cells apoptosis and S phase arrest. HDAC-IN-96 can be used for the research of cancer, such as acute lymphoblastic leukemia[1].

• CAS Number :

  [3055552-13-8]

• UNSPSC :

  12352005

• Target :

  Apoptosis; HDAC

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=CC=C(C=C1)CNC2=CC=CC(C(N3C4CCC(NC4=O)=O)=O)=C2C3=O)NC5=CC=C(C=C5N)F

• Molecular Formula :

  C27H22FN5O5

• Molecular Weight :

  515.49

• References & Citations :

  [1]Chen D, et al. Serendipitous discovery of Class I HDAC inhibitors from rational design of molecular glue degraders targeting HDAC. Eur J Med Chem. 2024 Jan 5;263:115926.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC2