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PROTAC SMARCA2 degrader-35

CAT: 0804-HY-176871Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176871Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC SMARCA2 degrader-35 (Compound 43) is a selective SMARCA2 PROTAC degrader with a DC50[2]. Pink: SMARCA2 ligand ; Blue: E3 ligase ligand; Black: linker
CAS Number
3032998-97-0
UNSPSC
12352005
Target
DNA/RNA Synthesis; PROTACs; SWI/SNF Complex
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
OC1=C(F)C=CC=C1C2=NN=C3C(N(C[C@H](OC4=NC=C(CN5CCN(C6=CC=C7C(C(N([C@@H]8C(NC(CC8)=O)=O)C7)=O)=C6)CC5)C=C4)C9)[C@@]9(C(F)F)CN3)=C2
Molecular Formula
C39H38F3N9O5
Molecular Weight
769.77
References & Citations
[1]Corey H B, et al. BRM Targeting Compounds And Associated Methods Of Use. US20240165244A1. 2024-05-23.|[2]Ito K, et al. Combination treatment regimens - smarca2 degrader with taxane anticancer agent. WO2025194059A1. 2025-09-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SMARCA2

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