PAD-PF2

• Description :

  PAD-PF2 is a PAD4 inhibitor with a Kd of 2.82 µM. PAD-PF2 inhibits Ionomycin (HY-13434) induced protein citrullination in human isolated neutrophils[1].

• UNSPSC :

  12352005

• Target :

  Protein Arginine Deiminase

• Related Pathways :

  Epigenetics

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(N1CCCC1)[C@@H](N)C2CCN(C3=NC=CC4=C3C=CC=C4C5=NC=C(Cl)C=C5Cl)CC2

• Molecular Formula :

  C25H27Cl2N5O

• Molecular Weight :

  484.42

• References & Citations :

  [1]Dakin LA, et al. Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site. Nat Commun. 2025 May 16;16 (1) :4579.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported