PAD-IN-4

• Description:

  PAD-IN-4 is a potent PAD inhibitor (PAD 1/4, IC50 = 0.273/0.24 μM) . PAD-IN-4 shows no significant cytotoxicity against A549 or MDA-MB-231 cells. PAD-IN-4 can be used for the study of cancer and autoimmune diseases[1].

• UNSPSC:

  12352005

• Target:

  Protein Arginine Deiminase

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  O=C(N[C@@H](CCCNC(CCl)=N)C(NCC1=CC=CC=C1)=O)C2=CC=C3C=C(O)C=CC3=C2

• Molecular Formula:

  C25H27ClN4O3

• Molecular Weight:

  466.96

• References & Citations:

  [1]Jia Y, et al. Discovery of highly potent naphthalene/quinoline-based PAD inhibitors: Structure-activity relationship, selectivity, and cytotoxicity. Eur J Med Chem. 2025 Oct 15;296:117830.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported