PAD4-IN-5

CAT: 0804-HY-173321Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-173321Size:1 Each

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Description

PAD4-IN-5 (Example 18) is a PAD4 inhibitor with IC50s of ≤10 nM and 101-500 nM for human PAD4 (hPAD4) under 50 µM Ca2+ and 1 mM Ca2+ conditions, respectively. PAD4-IN-5 can be used for the study of autoimmune disease, such as rheumatoid arthritis (RA) [1].

CAS Number

3071873-52-1

UNSPSC

12352005

Target

Protein Arginine Deiminase

Related Pathways

Epigenetics

Field of Research

Inflammation/Immunology

Smiles

O=C1C2=C(C=C(N(C)C(C3=CC4=C(N=C([C@H](N5)C)C=C4)N3CCCCC[C@@H]6C[C@H]6C5=O)=N7)C7=C2)CCN1C[C@H]8COCCN8

Molecular Formula

C34H41N7O3

Molecular Weight

595.73

References & Citations

[1]Makonen Belema, et al. Heterocyclic pad4 inhibitors. WO2025024288A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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