PAD4-IN-5

• Description :

  PAD4-IN-5 (Example 18) is a PAD4 inhibitor with IC50s of ≤10 nM and 101-500 nM for human PAD4 (hPAD4) under 50 µM Ca2+ and 1 mM Ca2+ conditions, respectively. PAD4-IN-5 can be used for the study of autoimmune disease, such as rheumatoid arthritis (RA) [1].

• UNSPSC :

  12352005

• Target :

  Protein Arginine Deiminase

• Related Pathways :

  Epigenetics

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C1C2=C(C=C(N(C)C(C3=CC4=C(N=C([C@H](N5)C)C=C4)N3CCCCC[C@@H]6C[C@H]6C5=O)=N7)C7=C2)CCN1C[C@H]8COCCN8

• Molecular Formula :

  C34H41N7O3

• Molecular Weight :

  595.73

• References & Citations :

  [1]Makonen Belema, et al. Heterocyclic pad4 inhibitors. WO2025024288A1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3071873-52-1]