PAD4-IN-5

• Description:

  PAD4-IN-5 (Example 18) is a PAD4 inhibitor with IC50s of ≤10 nM and 101-500 nM for human PAD4 (hPAD4) under 50 µM Ca2+ and 1 mM Ca2+ conditions, respectively. PAD4-IN-5 can be used for the study of autoimmune disease, such as rheumatoid arthritis (RA) [1].

• UNSPSC:

  12352005

• Target:

  Protein Arginine Deiminase

• Related Pathways:

  Epigenetics

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C1C2=C(C=C(N(C)C(C3=CC4=C(N=C([C@H](N5)C)C=C4)N3CCCCC[C@@H]6C[C@H]6C5=O)=N7)C7=C2)CCN1C[C@H]8COCCN8

• Molecular Formula:

  C34H41N7O3

• Molecular Weight:

  595.73

• References & Citations:

  [1]Makonen Belema, et al. Heterocyclic pad4 inhibitors. WO2025024288A1.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3071873-52-1]