PAD4-IN-4

CAT: 0804-HY-162494Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-162494Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

PAD4-IN-4 (compound 28) is a potent PAD4 inhibitor (IC50=0.79±0.09 μM) . PAD4-IN-4 improves the tumor immune microenvironment by reshaping neutrophil phenotype, upregulating the proportions of dendritic cells and M1 macrophages, and reducing the amount of myeloid-derived suppressor cells. PAD4-IN-4 can be used for Triple-negative breast cancer research[1].

UNSPSC

12352005

Target

Protein Arginine Deiminase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pad4-in-4.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(C(C3=CC=CC=C3)=N1)NC4=C2C=CC=C4)N[C@H](C(NCC5=CC=CC=C5)=O)CCCNC(CCl)=N

Molecular Formula

C32H31ClN6O2

Molecular Weight

567.08

References & Citations

[1]Zhu D, et al. A β-Carboline Derivate PAD4 Inhibitor Reshapes Neutrophil Phenotype and Improves the Tumor Immune Microenvironment against Triple-Negative Breast Cancer[J]. Journal of Medicinal Chemistry, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-157157	PAD4-IN-3
HY-173321	PAD4-IN-5
HY-155052-01	PAD4-IN-2
HY-155052A-01	PAD4-IN-2 (TFA)
HY-178365	PAD-IN-4
HY-175258	PAD2/4-IN-1
HY-W099255-01	Ethyl 4,4,4,4',4',4'-hexafluoro-DL-valinate
HY-W720006	4,4'-Diapo-ω, ω-carotene-4,4'-dial
HY-77910-01	4- (4-Bromophenyl) -4-hydroxypiperidine
HY-W014226	4,4'-Dihydroxybenzophenone

Alternative Products

Catalog	Name
GTR19262367-01	PAD4-IN-4
70R-13577	PAD4 antibody
BA4976-10	PAD4-IN-2
MBS483036-01	Anti-PAD4
GTR19258345-01	PAD4-IN-5
MBS515750-01	PAD4, Active
46-126P	PAD4 Peptide
EK6F921-01	Mouse Lipase-Like PAD4 (PAD4) ELISA Kit-Sandwich
C8757-5	PAD4-IN-2 TFA
GTR18225490	PADI4/PAD4 Antibody

PAD4-IN-4

Related Products

Alternative Products

Popular Products