PAD-IN-3

• Description :

  PAD-IN-3 (Compound 16) is a potent dual peptidyl arginine deiminases 4 (PAD4) and PAD1 inhibitor with IC50 values of 0.204 μM and 0.273 μM, respectively. PAD-IN-3 is promising for research of citrullination-associated disorders such as cancer and autoimmune diseases[1].

• UNSPSC :

  12352005

• Target :

  Protein Arginine Deiminase

• Related Pathways :

  Epigenetics

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  OC1=CC2=C(C=C1)C=CC(C(N[C@@H](CCCNC(CCl)=N)C(NCC3=CC=CC=C3)=O)=O)=C2

• Molecular Formula :

  C25H27ClN4O3

• Molecular Weight :

  466.96

• References & Citations :

  [1]Jia Y, et al. Discovery of highly potent naphthalene/quinoline-based PAD inhibitors: Structure-activity relationship, selectivity, and cytotoxicity. Eur J Med Chem. 2025 May 29;296:117830.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported