PAD-PF1

• Description:

  PAD-PF1 is a PAD4 inhibitor (IC50: 15.9 µM) . PAD-PF1 binds to an allosteric site of PAD-PF1, which is distinct from substrate and GSK147[1].

• UNSPSC:

  12352005

• Target:

  Protein Arginine Deiminase

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Smiles:

  O=C(N1CCCC1)C(N)C2CCN(C3=NC=NC4=C3C(C)=C(C)N4C5=CC=C(Br)C=C5)CC2

• Molecular Formula:

  C25H31BrN6O

• Molecular Weight:

  511.46

• References & Citations:

  [1]Dakin LA, et al. Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site. Nat Commun. 2025 May 16;16 (1) :4579.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported