CDK2-IN-46

• Description :

  CDK2-IN-46 (compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.3 nM. CDK2-IN-46 has a selectivity of >200-fold for CDK1, CDK7, CDK9, CDK4, and CDK6. CDK2-IN-46 shows improves rat and cyno pharmacokinetic profiles[1].

• CAS Number :

  [2498658-21-0]

• UNSPSC :

  12352005

• Target :

  CDK; Isotope-Labeled Compounds

• Related Pathways :

  Cell Cycle/DNA Damage; Others

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  O=C1C2(CC2)C3=CN=C(NC4=CC=C(C=C4)S(NC([2H])([2H])[2H])(=O)=O)N=C3N1[C@H]5C[C@@H](CCC5)O

• Molecular Formula :

  C21H22D3N5O4S

• Molecular Weight :

  446.54

• References & Citations :

  [1]Sokolsky A, et al. Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors. ACS Med Chem Lett. 2022 Oct 6;13 (11) :1797-1804.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported