AChE-IN-95

• Description:

  AChE-IN-95 (Compound 7) is a highly selective competitive acetylcholinesterase (AChE) inhibitor (IC50=17.87 μM, Ki=19.48 μM) . AChE-IN-95 exhibits strong cytotoxicity against SH-SY5Y neuroblastoma cells. AChE-IN-95 is promising for research of Alzheimer’s disease and neurodegenerative disorders[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  COC1=CC=CC(NC(CN2C(/C(SC2=O)=C/C3=CC(CN4CCN(C5=CC=CC=C5)CC4)=C(O)C(OC)=C3)=O)=O)=C1

• Molecular Formula:

  C31H32N4O6S

• Molecular Weight:

  588.67

• References & Citations:

  [1]Turgut GÇ, et al. Novel thiazolidinedione hybrids as cholinesterase inhibitors and targeting neuroblastoma: design, synthesis, in vitro and in silico biological evaluations. Bioorg Chem. 2025 Sep;164:108869.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE