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M2 ion channel blocker-2

CAT: 0804-HY-175804Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175804Size:1 Each
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Description
M2 ion channel blocker-2 (Compound 10) is a M2 channel blocker. M2 ion channel blocker-2 significantly blocks wild-type and mutant M2 (L27F and V27A) ion channels. M2 ion channel blocker-2 has potent antiviral activity against HCoV-229E (EC50: 4.7 μM in cytopathic effect) but not against influenza A virus. M2 ion channel blocker-2 has no significant inhibition of hERG and cytochrome P450 (CYP1A2, CYP2C19, and CYP3A4) activity[1].
CAS Number
2260797-32-6
UNSPSC
12352211
Target
SARS-CoV
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
NC12C[C@]3(C)C4(C)CC1CC4(C)C3(C)C2
Molecular Formula
C14H23N
Molecular Weight
205.34
References & Citations
[1]Turcu A L, et al. Exploring polycyclic scaffolds as adamantane replacements in M2 channel inhibitors of Influenza A virus[J]. bioRxiv, 2025: 2025.07. 26.666854.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

3,4,8,9-Tetramethyltetracyclo[4.4.0.03,9.04,8]decan-1-amine
CAS Number2260797-32-6
PubChem CID177933002
IUPAC Name3,4,8,9-tetramethyltetracyclo[4.4.0.03,9.04,8]decan-1-amine
Molecular FormulaC14H23N
Molecular Weight205.34
XLogP2.6
Topological Polar Surface Area26
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Heavy Atom Count15
Formal Charge0
Complexity357
SMILES
CC12CC3CC1(C4(C2(CC3(C4)N)C)C)C
InChI
InChI=1S/C14H23N/c1-10-5-9-6-11(10,2)13(4)8-14(9,15)7-12(10,13)3/h9H,5-8,15H2,1-4H3
InChIKey
DZHCHJHWLJHWIX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3,4,8,9-Tetramethyltetracyclo[4.4.0.03,9.04,8]decan-1-amine
CAS: 2260797-32-6
CID: 177933002
Formula: C14H23N
MW: 205.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight205.34
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass205.183049738
Monoisotopic Mass205.183049738
Topological Polar Surface Area26 Ų
Heavy Atom Count15
Formal Charge0
Complexity357
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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