DMT1 blocker 2

• Description :

  DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo[1].

• UNSPSC :

  12352005

• Target :

  Ferroportin

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/dmt1-blocker-2.html

• Purity :

  99.93

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OC1=C2C3=C(C=CC=C3)CCC2=NN1C4=NC=CC=C4

• Molecular Formula :

  C16H13N3O

• Molecular Weight :

  263.29

• References & Citations :

  [1]Cadieux JA, et, al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1) . Bioorg Med Chem Lett. 2012 Jan 1;22 (1) :90-5.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1062648-63-8]