NaV1.2/1.6 channel blocker-1

NaV1.2/1.6 channel blocker-1

• CAS Number: 1199944-04-1
• UNSPSC Description: NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy[1].
• Target Antigen: Sodium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/nav1-2-1-6-channel-blocker-1.html
• Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: S=C1OC2=CC=CC=C2C3=NC(C)=C(CCC)N13
• Molecular Weight: 258.34
• References & Citations: [1]Rivara M, et, al. Biological Evaluation of Imidazobenzoxazines, Imidazobenzoxazin-5-ones and Imidazobenzoxazin-5-thiones as Sodium Channel Blockers. Letters in Drug Design & Discovery, 2014, 11, 90-97.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported