N-type calcium channel blocker-1

• UNSPSC Description:

  N-type calcium channel blocker-1 is an orally active compound which shows high affinity to functionally block N-type calcium channels with an IC50 of 0.7 μM in the IMR32 assay.

• Target Antigen:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/N-type_calcium_channel_blocker-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C/C(C)=C\CN(C1=CC=C(CCC(C)(C)C)C=C1)C2CCN(CC3=CC=C(N(C)C)C=C3)CC2

• Molecular Weight:

  461.73

• References & Citations:

  [1]Hu LY, et al. The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phen yl]-(3-methyl-but-2-enyl)-amine, an N-type Ca+2 channel blocker with oral activity for analgesia. Bioorg Med Chem. 2000 Jun;8(6):1203-12.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  241499-17-2