(-) -KCC2 blocker 1

• Description:

  (-) -KCC2 blocker 1 is an enantiomer of KCC2 blocker 1 (HY-18172) . KCC2 blocker 1 (compound 13) is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM[1].

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Neurological Disease

• Purity:

  99.19

• Smiles:

  O=C(OCC1=CC=CC=C1)C2(CC3=CC=C(S(=O)(C)=O)C=C3)N(C(C)=O)CCC2

• Molecular Formula:

  C22H25NO5S

• Molecular Weight:

  415.50

• References & Citations:

  [1]Pégurier C, et al. Benzyl prolinate derivatives as novel selective KCC2 blockers. Bioorg Med Chem Lett. 2010 Apr 15;20 (8) :2542-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1228439-73-3]