VGSC blocker-1

VGSC blocker-1

• CAS Number: 2230472-55-4
• UNSPSC Description: VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability[1].
• Target Antigen: Sodium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/vgsc-blocker-1.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCCCN3CCCCC3)C=C1
• Molecular Weight: 386.52
• References & Citations: [1]Dutta S, et al. Discovery and evaluation of nNav1.5 sodium channel blockers with potent cell invasion inhibitory activity in breast cancer cells. Bioorg Med Chem. 2018;26(9):2428-2436.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported