STAT3-IN-46

• Description:

  STAT3-IN-46 is a selective and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3) (KD = 323.3 nM) . STAT3-IN-46 directly binds to the SH2 domain of the STAT3 and inhibits IL-6/JAK/STAT3 signaling pathway (IC50 = 0.87 μM) and downregulates c-Myc and Bcl-2 levels. STAT3-IN-46 can be used for the research of cancer, such as triple-negative breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Bcl-2 Family; c-Myc; Interleukin Related; JAK; STAT

• Related Pathways:

  Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  N#CC1=CC=CC(C2=NN=C(NC3=C(N4CCN(CC)CC4)C=C5N(C6CC6)C(C7=CC=C(F)C=C7)=NC5=C3)S2)=C1

• Molecular Formula:

  C31H29FN8S

• Molecular Weight:

  564.68

• References & Citations:

  [1]Wang R, et al. Discovery of potent and selective STAT3 inhibitors against triple-negative breast cancer. Eur J Med Chem. 2025 Nov 15;298:118020.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bcl-2; IL-6; STAT3