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BMS-986470

CAT: 0931-T210489-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T210489-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3036554-12-5
Target
Molecular Glues
Related Pathways
PROTAC
Bioactivity
BMS-986470 is a CRBN E3 ubiquitin ligase modulator (CELMoD) that activates fetal hemoglobin (HbF) . It is an orally available molecular glue degradator targeting ZBTB7A and WIZ protein degradation, thereby inducing gamma globin synthesis and activating HbF. It is applicable for studying sickle cell disease (SCD) .
Smiles
N(C1=C2C(C(=O)N(C2=O)[C@@H]3C(=O)NC(=O)CC3)=CC=C1)C4=C(C=C5C(=C4)N(C)C(=O)CC5)C=6C=C(C)N=CC6
Molecular Formula
C29H25N5O5
Molecular Weight
523.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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