BMS-986176

• Description:

  BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM. BMS-986176 can be used for neurodegenerative diseases research[1].

• Product Name Alternative:

  LX-9211; AAK1-IN-1

• UNSPSC:

  12352005

• Target:

  AAK1

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-986176.html

• Purity:

  98.79

• Solubility:

  DMSO : 220 mg/mL (ultrasonic)

• Smiles:

  CC(C)C[C@@](N)(C)COC1=C(C(F)F)N=C(C2=CC(C(F)F)=NC=C2)C=C1

• Molecular Formula:

  C19H23F4N3O

• Molecular Weight:

  385.40

• References & Citations:

  [1]Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.|[2]Guanglin Luo, et al. Discovery of (S) -1- ((2',6-Bis (difluoromethyl) -[2,4'-bipyridin]-5-yl) oxy) -2,4-dimethylpentan-2-amine (BMS-986176/LX-9211) : A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain. J Med Chem. 2022 Mar 24;65 (6) :4457-4480.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [1815613-42-3]