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BMS-986176

CAT: 0804-HY-134829-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134829-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM. BMS-986176 can be used for neurodegenerative diseases research[1].
CAS Number
1815613-42-3
Product Name Alternative
LX-9211; AAK1-IN-1
UNSPSC
12352005
Target
AAK1
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bms-986176.html
Purity
98.79
Solubility
DMSO : 220 mg/mL (ultrasonic)
Smiles
CC(C)C[C@@](N)(C)COC1=C(C(F)F)N=C(C2=CC(C(F)F)=NC=C2)C=C1
Molecular Formula
C19H23F4N3O
Molecular Weight
385.40
References & Citations
[1]Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.|[2]Guanglin Luo, et al. Discovery of (S) -1- ((2',6-Bis (difluoromethyl) -[2,4'-bipyridin]-5-yl) oxy) -2,4-dimethylpentan-2-amine (BMS-986176/LX-9211) : A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain. J Med Chem. 2022 Mar 24;65 (6) :4457-4480.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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