Immuno modulator-1

• Description :

  Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM[1].

• UNSPSC :

  12352005

• Target :

  Interleukin Related; Potassium Channel; TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/immuno-modulator-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@H](N1CCN(C2=C(C=C(C=N2)C#N)F)CC1)C(C=C3)=CC=C3COC4=C5C(C(N([C@@H]6C(NC(CC6)=O)=O)C5)=O)=CC=C4

• Molecular Formula :

  C32H31FN6O4

• Molecular Weight :

  582.62

• References & Citations :

  [1]Chen Xiangyang, et al. Heterocyclic immunomodulator. Patent, WO2022007659A1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IL-2

• CAS Number :

  [2757469-20-6]