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Immuno modulator-1

CAT: 0804-HY-153952Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-153952Size:1 Each
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Description
Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM[1].
CAS Number
[2757469-20-6]
UNSPSC
12352005
Target
Interleukin Related; Potassium Channel; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/immuno-modulator-1.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](N1CCN(C2=C(C=C(C=N2)C#N)F)CC1)C(C=C3)=CC=C3COC4=C5C(C(N([C@@H]6C(NC(CC6)=O)=O)C5)=O)=CC=C4
Molecular Formula
C32H31FN6O4
Molecular Weight
582.62
References & Citations
[1]Chen Xiangyang, et al. Heterocyclic immunomodulator. Patent, WO2022007659A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2

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