ClpP modulator-1

CAT: 0931-T212227-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T212227-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2363753-48-2
Target
Protease
Related Pathways
Proteases/Proteasome
Bioactivity
ClpPmodulator-1 (Compound BC8a) is a peptide mimic functioning as an allosteric ClpP modulator. At low concentrations, ClpPmodulator-1 acts as a ClpP activator, with EC50 values of 0.35 ?M for Neisseria meningitides ClpP (NmClpP) and 0.58 ?M for Escherichia coli ClpP (EcClpP) . At higher concentrations, it inhibits peptidase activity by competitively blocking substrate protein (LY-AMC) binding to the ClpPC site. ClpPmodulator-1 exhibits antibacterial properties and is applicable in bacterial infection research.
Smiles
[C@H](C(N[C@@H](CC(C)C)B(O)O)=O)(NC(=O)C1=C(Cl)C=C(OC)C=C1)CC(C)C
Molecular Formula
C19H30BClN2O5
Molecular Weight
412.72
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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