MRT-23227

CAT: 0804-HY-175453Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175453Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
MRT-23227 is a molecular glue degrader that targets cereblon (CRBN) . MRT-23227 forms a ternary complex with CRBN and G3BP2, activating the ubiquitin-proteasome system, leading to G3BP2 degradation. MRT-23227 has potential applications in the research of G3BP2-related cancers (such as breast and lung cancer) and neurodegenerative diseases[1].
CAS Number
[3050683-03-6]
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer; Neurological Disease
Smiles
O=C(C(C1=C(Cl)C(C2=CC=C(OCC3=NN(C)C=C3)C=C2)=CC=C1)CC4)NC4=O
Molecular Formula
C22H20ClN3O3
Molecular Weight
409.87
References & Citations
[1]Annunziato S, et al. Molecular surface mimicry enables CRBN to target G3BP2 for degradation. bioRxiv, 2025: 2025.04. 30.651496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-117903AMRT-92
HY-175437MRT-7612
HY-145387-01MRT-81
HY-108507-01MRT-10
HY-145918-01MRT-14
HY-153356-01MRT-2359
HY-175452-01MRT-3486
HY-175451MRT-10350
HY-174329Mrt-5702D
HY-118326MRT 68601

Alternative Products

CatalogName
T211823-01MRT-23227
MBS3617262-01MRT-14
MBS3845453-01MRT-83
JH920334MRT-2359
T211555-01MRT-3486
T211915-01MRT-10350
BUP03510-01MRT-81
BUP12443-01MRT-10
B7685-5MRT 10
T212146-01MRT-7612

Popular Products