MRT-23227

• Description :

  MRT-23227 is a molecular glue degrader that targets cereblon (CRBN) . MRT-23227 forms a ternary complex with CRBN and G3BP2, activating the ubiquitin-proteasome system, leading to G3BP2 degradation. MRT-23227 has potential applications in the research of G3BP2-related cancers (such as breast and lung cancer) and neurodegenerative diseases[1].

• UNSPSC :

  12352005

• Target :

  Molecular Glues

• Related Pathways :

  PROTAC

• Field of Research :

  Cancer; Neurological Disease

• Smiles :

  O=C(C(C1=C(Cl)C(C2=CC=C(OCC3=NN(C)C=C3)C=C2)=CC=C1)CC4)NC4=O

• Molecular Formula :

  C22H20ClN3O3

• Molecular Weight :

  409.87

• References & Citations :

  [1]Annunziato S, et al. Molecular surface mimicry enables CRBN to target G3BP2 for degradation. bioRxiv, 2025: 2025.04. 30.651496.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3050683-03-6]