MRT-23227

CAT: 0804-HY-175453Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175453Size:1 Each
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRT-23227 is a molecular glue degrader that targets cereblon (CRBN) . MRT-23227 forms a ternary complex with CRBN and G3BP2, activating the ubiquitin-proteasome system, leading to G3BP2 degradation. MRT-23227 has potential applications in the research of G3BP2-related cancers (such as breast and lung cancer) and neurodegenerative diseases[1].
CAS Number
[3050683-03-6]
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer; Neurological Disease
Smiles
O=C(C(C1=C(Cl)C(C2=CC=C(OCC3=NN(C)C=C3)C=C2)=CC=C1)CC4)NC4=O
Molecular Formula
C22H20ClN3O3
Molecular Weight
409.87
References & Citations
[1]Annunziato S, et al. Molecular surface mimicry enables CRBN to target G3BP2 for degradation. bioRxiv, 2025: 2025.04. 30.651496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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