MRT-23227

• Description:

  MRT-23227 is a molecular glue degrader that targets cereblon (CRBN) . MRT-23227 forms a ternary complex with CRBN and G3BP2, activating the ubiquitin-proteasome system, leading to G3BP2 degradation. MRT-23227 has potential applications in the research of G3BP2-related cancers (such as breast and lung cancer) and neurodegenerative diseases[1].

• UNSPSC:

  12352005

• Target:

  Molecular Glues

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer; Neurological Disease

• Smiles:

  O=C (C (C1=C (Cl) C (C2=CC=C (OCC3=NN (C) C=C3) C=C2) =CC=C1) CC4) NC4=O

• Molecular Formula:

  C22H20ClN3O3

• Molecular Weight:

  409.87

• References & Citations:

  [1]Annunziato S, et al. Molecular surface mimicry enables CRBN to target G3BP2 for degradation. bioRxiv, 2025: 2025.04. 30.651496.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3050683-03-6