MRT-7612

• Description :

  MRT-7612 (Compound 4) is a cereblon-based tyrosine kinases molecular glue degrader. MRT-7612 significantly induces HCK and LYN degradation, with week efficacy on LCK. MRT-7612 can be used for cancers like chronic myeloid leukemia, autoimmune and chronic inflammatory diseases research[1].

• UNSPSC :

  12352005

• Target :

  Bcr-Abl; Molecular Glues; Src

• Related Pathways :

  PROTAC; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  O=C(N1CC2(CCC3=C2C=CC=C3)C1)NC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O

• Molecular Formula :

  C25H24N4O4

• Molecular Weight :

  444.48

• References & Citations :

  [1]Petzold G, et al. Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition. Science. 2025 Jul 3;389 (6755) :eadt6736.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Hck; Lck; Lyn