MRT-7612

• Description:

  MRT-7612 (Compound 4) is a cereblon-based tyrosine kinases molecular glue degrader. MRT-7612 significantly induces HCK and LYN degradation, with week efficacy on LCK. MRT-7612 can be used for cancers like chronic myeloid leukemia, autoimmune and chronic inflammatory diseases research[1].

• UNSPSC:

  12352005

• Target:

  Bcr-Abl; Molecular Glues; Src

• Related Pathways:

  PROTAC; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  O=C(N1CC2(CCC3=C2C=CC=C3)C1)NC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O

• Molecular Formula:

  C25H24N4O4

• Molecular Weight:

  444.48

• References & Citations:

  [1]Petzold G, et al. Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition. Science. 2025 Jul 3;389 (6755) :eadt6736.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Hck; Lck; Lyn