MRT-10350

• Description:

  MRT-10350 (Compound 2) is a cereblon-based HCK molecular glue degrader. MRT-10350 can be used for cancers like chronic myeloid leukemia and HIV-1 infections research[1].

• UNSPSC:

  12352005

• Target:

  Molecular Glues; Src

• Related Pathways:

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Smiles:

  O=C(NC1(C2=CC=C(SC)C=C2)COCC1)NC3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4)=O)C=C3

• Molecular Formula:

  C25H26N4O5S

• Molecular Weight:

  494.56

• References & Citations:

  [1]Petzold G, et al. Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition. Science. 2025 Jul 3;389 (6755) :eadt6736.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Hck