MRT-3486

• Description :

  MRT-3486 (Compound 5) is a cereblon-based NEK7 molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research[1].

• UNSPSC :

  12352005

• Target :

  Molecular Glues; NEKs

• Related Pathways :

  Cell Cycle/DNA Damage; PROTAC

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Purity :

  99.6200

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C([C@H]1N(S(=O)(CC2=CC=CC=C2)=O)CC3=C(C=CC=C3)C1)NCC4=CC5=NC=C(N(C(N6)=O)CCC6=O)N5C=C4

• Molecular Formula :

  C29H28N6O5S

• Molecular Weight :

  572.63

• References & Citations :

  [1]Petzold G, et al. Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition. Science. 2025 Jul 3;389 (6755) :eadt6736.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NEK7