MRT-92

• Description :

  MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM) . MRT-92 can be used in the study of cerebellar glioma[1].

• UNSPSC :

  12352005

• Target :

  Hedgehog; Smo

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mrt-92.html

• Smiles :

  O=C(NC(NC1=CC=C(C)C(NC(C2=CC=C(CCC3=CC=CC=C3)C=C2)=O)=C1)=N)C4=CC(OC)=C(OC)C(OC)=C4

• Molecular Formula :

  C33H34N4O5

• Molecular Weight :

  566.65

• References & Citations :

  [1]Hoch, et al. "MRT-92 inhibits Hedgehog signaling by blocking overlap** binding sites in the transmembrane domain of the Smoothened receptor." The FASEB Journal 29.5 (2015) : 1817.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1428315-82-5]