MRT-92

• UNSPSC Description:

  MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM). MRT-92 can be used in the study of cerebellar glioma[1].

• Target Antigen:

  Hedgehog; Smo

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mrt-92.html

• Smiles:

  O=C(NC(NC1=CC=C(C)C(NC(C2=CC=C(CCC3=CC=CC=C3)C=C2)=O)=C1)=N)C4=CC(OC)=C(OC)C(OC)=C4

• Molecular Weight:

  566.65

• References & Citations:

  [1]Hoch, et al. "MRT-92 inhibits Hedgehog signaling by blocking overlap** binding sites in the transmembrane domain of the Smoothened receptor." The FASEB Journal 29.5 (2015): 1817.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1428315-82-5