MRT-23227

• Target:

  Molecular Glues

• Related Pathways:

  PROTAC

• Bioactivity:

  MRT-23227 is a molecular glue degrader targeting cereblon (CRBN) . It forms a ternary complex with CRBN and G3BP2, which activates the ubiquitin-proteasome system to degrade G3BP2. MRT-23227 shows potential for research in G3BP2-related cancers (such as breast cancer and lung cancer) and neurodegenerative diseases.

• Smiles:

  O=C1NC(=O)C(C=2C=CC=C(C=3C=CC(OCC4=NN(C=C4)C)=CC3)C2Cl)CC1

• Molecular Formula:

  C22H20ClN3O3

• Molecular Weight:

  409.87

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3050683-03-6