Mrt-5702D

• Description:

  Mrt-5702D is a molecular glue degrader targeting cereblon (CRBN) . mrt-5702D forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. mrt-5702D is promising for research of G3BP2-related cancers (e.g., breast cancer, lung cancer) and neurodegenerative diseases[1].

• UNSPSC:

  12352005

• Target:

  Molecular Glues

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer; Neurological Disease

• Smiles:

  C[C@H]1C2=CC=CC=C2C[C@H] (N1S (=O) (CC3=CC=CC=C3Cl) =O) C (NCC4=CC5=NC=C (N5C=C4) N6CCC (NC6=O) =O) =O

• Molecular Formula:

  C30H29ClN6O5S

• Molecular Weight:

  621.11

• References & Citations:

  [1]Annunziato S, et al. Molecular surface mimicry enables CRBN to target G3BP2 for degradation[J]. bioRxiv, 2025: 2025.04. 30.651496.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported