Mrt-5702D

• Description :

  Mrt-5702D is a molecular glue degrader targeting cereblon (CRBN) . mrt-5702D forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. mrt-5702D is promising for research of G3BP2-related cancers (e.g., breast cancer, lung cancer) and neurodegenerative diseases[1].

• UNSPSC :

  12352005

• Target :

  Molecular Glues

• Related Pathways :

  PROTAC

• Field of Research :

  Cancer; Neurological Disease

• Smiles :

  C[C@H]1C2=CC=CC=C2C[C@H](N1S(=O)(CC3=CC=CC=C3Cl)=O)C(NCC4=CC5=NC=C(N5C=C4)N6CCC(NC6=O)=O)=O

• Molecular Formula :

  C30H29ClN6O5S

• Molecular Weight :

  621.11

• References & Citations :

  [1]Annunziato S, et al. Molecular surface mimicry enables CRBN to target G3BP2 for degradation[J]. bioRxiv, 2025: 2025.04. 30.651496.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported