MRT-2359

CAT: 1266-JH920334Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:1266-JH920334Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

2803881-11-8

Chemical Information

[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]methyl N-[2-fluoro-5-(trifluoromethoxy)phenyl]carbamate

GSPT1 MGD MRT-2359 is an orally bioavailable selective molecular glue degrader (MGD) of the translational termination factor GSPT1, with potential antineoplastic activity. Upon oral administration, MRT-2359 targets and binds to GSPT1, thereby promoting complex formation between the E3 ubiquitin ligase component cereblon (CRBN) and GSPT1, and inducing GSPT1 degradation in a CRBN- and degron-dependent manner. This downregulates L-MYC and N-MYC, thereby disrupting MYC-driven protein translation and reducing MYC-oncogenic signaling. This inhibits proliferation in MYC-driven tumors. The translation termination factor GSPT1, a G-loop degron-containing protein, plays a key role in protein translation in MYC-driven cancers.

CAS Number	2803881-11-8
PubChem CID	164584214
IUPAC Name	[2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]methyl N-[2-fluoro-5-(trifluoromethoxy)phenyl]carbamate
Molecular Formula	C22H17F4N3O6
Molecular Weight	495.4
XLogP	2.5
Topological Polar Surface Area	114
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Heavy Atom Count	35
Formal Charge	0
Complexity	856

SMILES

C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=C(C=C3)COC(=O)NC4=C(C=CC(=C4)OC(F)(F)F)F

InChI

InChI=1S/C22H17F4N3O6/c23-15-4-3-13(35-22(24,25)26)8-16(15)27-21(33)34-10-11-1-2-12-9-29(20(32)14(12)7-11)17-5-6-18(30)28-19(17)31/h1-4,7-8,17H,5-6,9-10H2,(H,27,33)(H,28,30,31)

InChIKey

HNTGMIGBGVFOBT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2803881-11-8

CID: 164584214

Formula: C22H17F4N3O6

MW: 495.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	495.4
XLogP3	2.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	495.10534792
Monoisotopic Mass	495.10534792
Topological Polar Surface Area	114 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	856
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
M36092-01	MRT-2359
GTR19198489	NS-2359 citrate
T211915-01	MRT-10350
T211555-01	MRT-3486
HY-175453	MRT-23227
HY-175437	MRT-7612
HY-117903A	MRT-92
T9531-01	MRT-14
MBS3845453-01	MRT-83
BUP12443-01	MRT-10

MRT-2359

Chemical Information

Alternative Products

Popular Products