MRT-83

• Description :

  MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Smo

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/MRT-83.html

• Purity :

  99.27

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  COC1=C(OC)C(OC)=CC(C(NC(NC2=CC(NC(C3=CC=C(C4=CC=CC=C4)C=C3)=O)=C(C)C=C2)=N)=O)=C1

• Molecular Formula :

  C31H30N4O5

• Molecular Weight :

  538.59

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Roudaut H, et al. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol Pharmacol. 2011 Mar;79 (3) :453-60.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1263131-92-5]