AChE-IN-92

• Description:

  AChE-IN-92 (Compound L4R1-3) is a highly selective acetylcholinesterase (AChE) inhibitor (IC50=4.6 nM) . AChE-IN-92 blocks acetylcholine hydrolysis and elevates synaptic acetylcholine levels. AChE-IN-92 is promising for research of Alzheimer’s disease (AD) [1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  COC(C(OC)=C1)=CC2=C1N=CC=C2NC3=CC(CN(CC)CC)=C(O)C=C3

• Molecular Formula:

  C22H27N3O3

• Molecular Weight:

  381.47

• References & Citations:

  [1]Sun D, et al. Fragment-informed SAR: rational construction of quinoline derivatives as dual AChE/BChE inhibitors. Bioorg Chem. 2025 Aug;163:108747.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE

• CAS Number:

  [2421120-68-3]