AChE-IN-92

• Description :

  AChE-IN-92 (Compound L4R1-3) is a highly selective acetylcholinesterase (AChE) inhibitor (IC50=4.6 nM) . AChE-IN-92 blocks acetylcholine hydrolysis and elevates synaptic acetylcholine levels. AChE-IN-92 is promising for research of Alzheimer’s disease (AD) [1].

• UNSPSC :

  12352005

• Target :

  Cholinesterase (ChE)

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  COC(C(OC)=C1)=CC2=C1N=CC=C2NC3=CC(CN(CC)CC)=C(O)C=C3

• Molecular Formula :

  C22H27N3O3

• Molecular Weight :

  381.47

• References & Citations :

  [1]Sun D, et al. Fragment-informed SAR: rational construction of quinoline derivatives as dual AChE/BChE inhibitors. Bioorg Chem. 2025 Aug;163:108747.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE

• CAS Number :

  [2421120-68-3]