ISO-92

• Description :

  ISO-92 in an inhibitor of MIF. ISO-92 selectively inhibits MIF inflammatory activity with an IC50 of 550 nM. ISO-92 inhibits hypoxia-induced proliferation of CCL-210 cell line dose-dependently. ISO-92 significantly reduces the thickness of pulmonary vascular wall in mouse hypoxia models. ISO-92 can be studied in inflammatory and neurological research[1][2].

• CAS Number :

  [899433-49-9]

• UNSPSC :

  12352005

• Target :

  Macrophage migration inhibitory factor (MIF)

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Smiles :

  O=C(OCC(C)(C)C)C[C@H]1CC(C2=CC=C(O)C(F)=C2)=NO1

• Molecular Formula :

  C16H20FNO4

• Molecular Weight :

  309.33

• References & Citations :

  [1]Perveen, S., et al., (2019) . MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia. Pediatric research, 85 (5), 711-718. |[2]Zhang, Y., et al., (2012) . Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension. Molecular medicine (Cambridge, Mass.), 18 (1), 215-223.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported