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HDAC-IN-92

CAT: 0804-HY-175857Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175857Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-92 is a pan-HDAC inhibitor with an IC50 of 12.58 µM in A2780 cells. HDAC-IN-92 demonstrates broad-spectrum, notable cytotoxic activity against a range of human cancer cell lines, including ovarian, liver, and breast carcinomas. HDAC-IN-92 causes apoptosis and demonstrates a notable decrease in tumor cell colony formation. HDAC-IN-92 inhibits the formation of blood vessels in the chick chorioallantoic membrane (CAM) . HDAC-IN-92 exhibits anti-tumor effect in a 4T1 tumor-bearing mouse model. HDAC-IN-92 can be used for research targeting solid tumor[1].
UNSPSC
12352005
Target
Apoptosis; HDAC
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NO)C1=CC=C(/N=C/C2=CN=C(SCC3=CC=CC(F)=C3)N2C)C=C1
Molecular Formula
C19H17FN4O2S
Molecular Weight
384.43
References & Citations
[1]Jamshidi Z, et al. Novel imidazolyl-hydroxamic acid Schiff base scaffold derivatives as histone deacetylase inhibitors: Design, synthesis, and biological assessment. Bioorg Chem. 2025 Sep;164:108879.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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