KN-92

CAT: 0804-HY-15517-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15517-01Size:5 mg
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Description
KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2].
CAS Number
[176708-42-2]
UNSPSC
12352005
Target
CaMK
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kn-92.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)=O
Molecular Formula
C24H25ClN2O3S
Molecular Weight
456.98
References & Citations
[1]Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277 (38) :35061-35070.|[2]An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13 (9) :1445-1448.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cell Calcium. 2021 Dec:100:102483.|Commun Biol. 2025 Mar 12;8 (1) :417.|J Mol Cell Cardiol. 2022 Mar:164:110-125.|J Endocrinol. 2018 Mar;236 (3) :151-165. |Nat Metab. 2020 Sep;2 (9) :918-933.|Sci Rep. 2023 Dec 7;13 (1) :21712.

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Alternative Products

CatalogName
462558KN-92
255603KN 92
B1643-25KN-92 hydrochloride
M17153-01KN-92 phosphate
A15137-25KN-92 25mg
A15137-50KN-92 50mg
A15137-100KN-92 100mg

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