KN-92

• Description:

  KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2].

• UNSPSC:

  12352005

• Target:

  CaMK

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/kn-92.html

• Purity:

  99.91

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)=O

• Molecular Formula:

  C24H25ClN2O3S

• Molecular Weight:

  456.98

• References & Citations:

  [1]Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277 (38) :35061-35070.|[2]An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13 (9) :1445-1448.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  Cell Calcium. 2021 Dec:100:102483.|Commun Biol. 2025 Mar 12;8 (1) :417.|J Mol Cell Cardiol. 2022 Mar:164:110-125.|J Endocrinol. 2018 Mar;236 (3) :151-165. |Nat Metab. 2020 Sep;2 (9) :918-933.|Sci Rep. 2023 Dec 7;13 (1) :21712.

• CAS Number:

  [176708-42-2]