STAT-3/c-Src-IN-1

• Description :

  STAT-3/c-Src-IN-1 (Compound 12d) is a dual STAT-3 (IC50=0.844 μM) and c-Src (IC50=0.268 μM) inhibitor. STAT-3/c-Src-IN-1 blocks tumor cell proliferation, migration, and angiogenesis signaling pathways. STAT-3/c-Src-IN-1 exhibits potent anti-proliferative activity against melanoma (SK-MEL-2) and CNS cancer (SNB-75) cell lines (GI50=-5.75 μM and -5.63 μM), inducing tumor cell apoptosis via G0/G1 and G2/M phase cell cycle arrest. STAT-3/c-Src-IN-1 is promising for research of melanoma and glioblastoma[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Src; STAT

• Related Pathways :

  Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  O=C(CN1C(C2=CC=CC=C2N=C1C)=O)N/N=C/C3=CN(C4=CC=C(C=C4)S(=O)(C)=O)N=C3C(C=C5)=CC=C5[N+]([O-])=O

• Molecular Formula :

  C28H23N7O6S

• Molecular Weight :

  585.59

• References & Citations :

  [1]Abdelall EKA, et al. Development of novel quinazolinone-based compounds with anti-proliferative activity as dual STAT-3 and c-Src inhibitors: design, synthesis and molecular dynamic studies. Bioorg Chem. 2025 Aug;163:108753.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  STAT3