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STAT-3 Antibody

CAT: 0800-F46167-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F46167-0.08MLSize:0.08 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:200
UniProt
P40763
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 711-743 from the human protein was used as the immunogen for this STAT-3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the STAT-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This STAT-3 antibody is available for research use only.
Storage Conditions
Aliquot the STAT-3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the STAT-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
STAT-3 antibody western blot analysis in Daudi lysate. Predicted/observed molecular weight ~88kDa.

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