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PAD2/4-IN-1

CAT: 0804-HY-175258Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175258Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PAD2/4-IN-1 (Compound 4f) is an orally active inhibitor of PAD2 and PAD4 with IC50 values of 23 nM and 10 nM, respectively. PAD2/4-IN-1 can inhibit protein citrullination in neutrophils and reduce hERG channel liabilities. PAD2/4-IN-1 can be used in the research of autoimmune diseases, neurological disorders, and cancers[1].
UNSPSC
12352005
Target
Potassium Channel; Protein Arginine Deiminase
Related Pathways
Epigenetics; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Smiles
O=C(NC)[C@@H](N)C1CCN(C2=NC=CC3=C2C=CC=C3C4=NC(C5=NN(C)C=C5)=C(Cl)C=C4Cl)CC1
Molecular Formula
C26H27Cl2N7O
Molecular Weight
524.44
References & Citations
[1]Schnute M E, et al. Peptidylarginine Deiminase (PAD) Inhibitor Optimization through Displacement of a Trapped Water Molecule. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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