PAD2 (human, recombinant)

• Description:

  PAD2 (Human, Recombinant)_x000D_ Catalog number: B2017267_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 ug_x000D_ Molecular Weight or Concentration: 77.32 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: PADI2, PAD-H19, Peptidylarginine Deiminase 2, Protein Arginine Deiminase 2_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis Matrix Biol. 2021 Aug;102:70-84._x000D_ 2: Martin M, Nilsson SC, Eikrem D, Fromell K, Scavenius C, Vogt LM, Bielecka E, Potempa J, Enghild JJ, Nilsson B, Ekdahl KN, Kapetanovic MC, Blom AM. Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis Front Immunol. 2023 Jun 22;14:1203506._x000D_ 3: Martens CP, Peetermans M, Vanassche T, Verhamme P, Jacquemin M, Martinod K. Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteraemia Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20230042._x000D_ 4: Sharma M, Damgaard D, Senolt L, Svensson B, Bay-Jensen AC, Nielsen CH, Hägglund P. Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients J Proteomics. 2019 Sep 30;208:103484._x000D_ 5: Wood DD, Ackerley CA, Brand Bv, Zhang L, Raijmakers R, Mastronardi FG, Moscarello MA. Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities Lab Invest. 2008 Apr;88(4):354-64._x000D_ 6: Jang B, Shin HY, Choi JK, Nguyen du PT, Jeong BH, Ishigami A, Maruyama N, Carp RI, Kim YS, Choi EK. Subcellular localization of peptidylarginine deiminase 2 and citrullinated proteins in brains of scrapie-infected mice: nuclear localization of PAD2 and membrane fraction-enriched citrullinated proteins J Neuropathol Exp Neurol. 2011 Feb;70(2):116-24._x000D_ 7: Zhou Y, Mittereder N, Sims GP. Perspective on Protein Arginine Deiminase Activity-Bicarbonate Is a pH-Independent Regulator of Citrullination Front Immunol. 2018 Jan 18;9:34._x000D_ 8: Damgaard D, Bawadekar M, Senolt L, Stensballe A, Shelef MA, Nielsen CH. Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3 PLoS One. 2018 Aug 30;13(8):e0203214._x000D_ 9: Choudhury RH, Symonds P, Paston SJ, Daniels I, Cook KW, Gijon M, Metheringham RL, Brentville VA, Durrant LG. PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy J Immunother Cancer. 2022 Feb;10(2):e003526._x000D_ 10: Ranaivoson FM, Bande R, Cardaun I, De Riso A, Gärtner A, Loke P, Reinisch C, Vogirala P, Beaumont E. Crystal structure of human peptidylarginine deiminase type VI (PAD6) provides insights into its inactivity IUCrJ. 2024 May 1;11(Pt 3):395-404. _x000D_ _x000D_ Products Related to PAD2 (Human, Recombinant) can be found at Proteins

• Short Description:

  Catalog Number: B2017267 (50 ug)_x000D_ PAD2 (Human, Recombinant) is the human form of the enzyme peptidyl arginine deiminase type 2 (PAD2) produced through recombinant DNA technology. PAD2 modifies proteins by converting arginine residues into citrulline, affecting protein function, structure, and interactions. Recombinant PAD2 is produced by inserting the PAD2 gene into an expression system, enabling controlled and reproducible studies of the enzyme's function and regulation. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3