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α4β1 antagonist-1

CAT: 0804-HY-175286Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175286Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α4β1 antagonist-1 (Compound 4) is a highly selective α4β1 integrin antagonist (IC50=15 nM) . α4β1 antagonist-1 inhibits integrin-mediated cell adhesion and ERK1/2 signaling activation. α4β1 antagonist-1 also exhibits partial agonism toward αMβ2 integrin (EC50=23 nM) . α4β1 antagonist-1 is promising for research of chronic inflammatory diseases (e.g., rheumatoid arthritis, multiple sclerosis) and cancers[1].
UNSPSC
12352005
Target
ERK; Integrin
Related Pathways
Cytoskeleton; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
[NH3+]C1=CC=C(C=C1)CC(N2CCC[C@H]2C(O)=O)=O.O=C([O-])C(F)(F)F
Molecular Formula
C15H17F3N2O5
Molecular Weight
362.30
References & Citations
[1]Giraldi V, et al. Targeting α4β1 integrin: from cyclic to linear ligands, effects of chemical modifications. Eur J Med Chem. 2025 Nov 5;297:117965.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2; α4β1

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