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ITK-IN-6

CAT: 0804-HY-174903-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-174903-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ITK-IN-6 is a highly potent and selective ITK inhibitor (Kd = 387 nM) . ITK-IN-6 directly binds to the ITK kinase domain. ITK-IN-6 blocks the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus and IgE production. ITK-IN-6 significantly inhibits airway inflammation and is used in asthma research[1].
CAS Number
2616666-32-9
UNSPSC
12352005
Target
Itk
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
OC1=C(NS(=O)(C)=O)C=C(NC(C2=CC=C(C3=C(Cl)C(Cl)=CC=C3)C=C2)=O)C=C1
Molecular Formula
C20H16Cl2N2O4S
Molecular Weight
451.32
References & Citations
[1]Zhaoxi Guo, et al. A Novel Small Molecule ITK Inhibitor Suppresses Th2/Th17 Differentiation and Attenuates Airway Inflammation in a Mouse Model of HDM-Induced Asthma. Immunology. 2025 Jun 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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