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ITK inhibitor 6

CAT: 0931-T63229-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T63229-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2404604-06-2
Target
Others, Tyrosine Kinases
Related Pathways
Others, Tyrosine Kinase/Adaptors
Bioactivity
ITK inhibitor 6 is a selective and potent ITK inhibitor that acts on ITK (IC50: 4 nM), BTK (IC50: 133 nM), JAK3 (IC50: 320 nM), EGFR (IC50: 2360 nM), LCK (IC50: 155 nM) . ITK inhibitor 6 inhibited the phosphorylation of PLCγ1 and ERK1/2 and showed anti-proliferative effect.
Smiles
O(CCNC(C=C)=O)C1=C2C=C(NC2=CC(CC3=CC=CC=C3)=C1)C=4C=5C(NN4)=CC(C(F)F)=CC5
Molecular Formula
C28H24F2N4O2
Molecular Weight
486.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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