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ITK-IN-6

CAT: 0931-T210969-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210969-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2616666-32-9
Target
Tyrosine Kinases
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
ITK-IN-6 is a potent and selective ITK inhibitor (Kd = 387 nM) . It binds directly to the ITK kinase domain. This compound prevents the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus production, and IgE generation. It significantly inhibits airway inflammation and is used in asthma research.
Smiles
O=C(NC1=CC=C(O)C(=C1)NS(=O)(=O)C)C2=CC=C(C=C2)C=3C=CC=C(Cl)C3Cl
Molecular Formula
C20H16Cl2N2O4S
Molecular Weight
451.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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