PQM-244

• Description:

  PQM-244 (Compound 5c) is an orally active and multi-target modulator of TRPV1 and CB1 and CB2 receptors. PQM-244 has significant peripheral antinociceptive effects on both neurogenic and inflammatory phases. PQM-244 also has potential antioxidant activity with an IC50 of 14.15 µM for radical scavenging DPPH. PQM-244 can be used for chronic pain and inflammatory disease research, such as diabetes, atherosclerosis and Alzheimer’s disease[1].

• UNSPSC:

  12352005

• Target:

  Cannabinoid Receptor; TRP Channel

• Related Pathways:

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  CC1=CC[C@H] (C (C) =C) C/C1=N\NC (C2=CC=C (OC) C=C2) =O

• Molecular Formula:

  C18H22N2O2

• Molecular Weight:

  298.38

• References & Citations:

  [1]Dos Reis Rosa Franco G, et al. New cannabidiol structure-related terpene N-acyl-hydrazones with potent antinociceptive and anti-inflammatory activity. Future Med Chem. 2025 Jun 16:1-12.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  316139-50-1