NUV-244

• Description :

  NUV-244 is a PNPLA3 I148M degrader. NUV-244 reduces PNPLA3 I148M levels on lipid droplets via BFAR-mediated ubiquitin-proteasome degradation[1].

• UNSPSC :

  12352005

• Target :

  PNPLA3

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Smiles :

  CC1=CC(CC2=NC(C)=C(C(NC3=CC(O)=CC=C3Cl)=O)S2)=CC=C1

• Molecular Formula :

  C19H17ClN2O2S

• Molecular Weight :

  372.87

• References & Citations :

  [1]Steigemann P, et al. Identification of NUV-244 as a PNPLA3 I148M degrading small molecule. iScience. 2025 Apr 8;28 (5) :112384.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported