NUV-244

• Description:

  NUV-244 is a PNPLA3 I148M degrader. NUV-244 reduces PNPLA3 I148M levels on lipid droplets via BFAR-mediated ubiquitin-proteasome degradation[1].

• UNSPSC:

  12352005

• Target:

  PNPLA3

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  CC1=CC (CC2=NC (C) =C (C (NC3=CC (O) =CC=C3Cl) =O) S2) =CC=C1

• Molecular Formula:

  C19H17ClN2O2S

• Molecular Weight:

  372.87

• References & Citations:

  [1]Steigemann P, et al. Identification of NUV-244 as a PNPLA3 I148M degrading small molecule. iScience. 2025 Apr 8;28 (5) :112384.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported