DPP-4-IN-16

• Description:

  DPP-4-IN-16 (Compound 92) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor (IC50=0.8 nM) . DPP-4-IN-16 inhibits DPP-4-mediated degradation of incretins (e.g., GLP-1 and GIP) to promote insulin secretion and reduce blood glucose. DPP-4-IN-16 is promising for research of type 2 diabetes[1].

• UNSPSC:

  12352005

• Target:

  Dipeptidyl Peptidase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Smiles:

  [H]C1=C(N(C(N(C1=O)CC#CC)=O)N2CCC[C@@H](N)C2)CC3=C(Br)C=CC(C(O)=O)=C3

• Molecular Formula:

  C21H23BrN4O4

• Molecular Weight:

  475.34

• References & Citations:

  [1]Kohal R, et al. Pyrimidine‐2, 4‐dione‐Based DPP‐4 Inhibitors: A Structure‐Guided Multifaced 3D‐QSAR and Molecular Dynamics Studies[J]. ChemistrySelect, 2025, 10 (22) : e00268.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  DPP-4