HDAC-IN-90

• Description:

  HDAC-IN-90 is the ligand for HDAC6/10 that can be used for synthesis of PROTAC HDAC degrader-2 (HY-174444) [1].

• UNSPSC:

  12352005

• Target:

  HDAC; Ligands for Target Protein for PROTAC

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics; PROTAC

• Field of Research:

  Cancer

• Smiles:

  O=C (NO) C (C=C1) =CC=C1CN2C3=CC=CC=C3C4=C2CCN (C (OC (C) (C) C) =O) C4

• Molecular Formula:

  C24H27N3O4

• Molecular Weight:

  421.49

• References & Citations:

  [1]Zhai S, et al. Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders. J Med Chem. 2025 Jul 10;68 (13) :13793-13821.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1354547-28-6