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AChE-IN-90

CAT: 0804-HY-174462Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174462Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE-IN-90 (Compound 5b) is an orally active, brain-penetrant and potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.023 μM against human AChE and lower selectivity for butyrylcholinesterase (BuChE) (IC50 1.8 μM) . AChE-IN-90 increases acetylcholine levels in the synaptic cleft. AChE-IN-90 is promising for research of neurodegenerative diseases such as Alzheimer's disease[1].
UNSPSC
12352005
Target
Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(OC(C)(C)C)NC1CN(C(/C=C/C2=CC=CC=C2Cl)=O)CCC1
Molecular Formula
C19H25ClN2O3
Molecular Weight
364.87
References & Citations
[1]Jacob B, et al. Light-induced negative differential resistance and neural oscillations in neuromorphic photonic semiconductor micropillar sensory neurons. Sci Rep. 2025 Feb 25;15 (1) :6805.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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