AChE-IN-90

• Description:

  AChE-IN-90 (Compound 5b) is an orally active, brain-penetrant and potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.023 μM against human AChE and lower selectivity for butyrylcholinesterase (BuChE) (IC50 1.8 μM) . AChE-IN-90 increases acetylcholine levels in the synaptic cleft. AChE-IN-90 is promising for research of neurodegenerative diseases such as Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(OC(C)(C)C)NC1CN(C(/C=C/C2=CC=CC=C2Cl)=O)CCC1

• Molecular Formula:

  C19H25ClN2O3

• Molecular Weight:

  364.87

• References & Citations:

  [1]Jacob B, et al. Light-induced negative differential resistance and neural oscillations in neuromorphic photonic semiconductor micropillar sensory neurons. Sci Rep. 2025 Feb 25;15 (1) :6805.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE